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Updated: Jun 23, 2025

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
06:24

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

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单细胞染色体可访问性分析揭示了脑髓母细胞瘤中特定子组的TF-NTR调节电路

Xiaoyue Gao1,2, Qiyuan Zhuang3,4, Yun Li1,2

  • 1CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|June 17, 2024
PubMed
概括

这项研究使用单细胞ATAC测序来绘制儿科骨髓母细胞瘤 (MB) 染色质可访问性的地图. 研究人员确定了特定子组的调控元素和转录因子,揭示了神经递质受体作为MB的潜在治疗点.

关键词:
染色质可访问性 景观脑髓母细胞瘤是什么意思神经递质受体的神经递质受体单细胞转移酶可访问的染色体测序.

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Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
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