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相关概念视频

Olfaction01:25

Olfaction

44.3K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
44.3K
Working Memory01:24

Working Memory

155
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
155
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

8.3K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
8.3K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

9.2K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.2K

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相关实验视频

Updated: Jun 23, 2025

Olfactory Context Dependent Memory: Direct Presentation of Odorants
04:47

Olfactory Context Dependent Memory: Direct Presentation of Odorants

Published on: September 18, 2018

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嗅觉工作记忆容量范式

Lixin Jiang1,2,3, Gengdi Huang4,5, Xin Yu1,2,3

  • 1Peking University Institute of Mental Health (Sixth Hospital), Beijing, China.

Current protocols
|June 17, 2024
PubMed
概括
此摘要是机器生成的。

研究人员开发了一种新的嗅觉工作记忆能力 (OWMC) 范式,以测量动物的工作记忆. 本协议详细说明了OWMC任务,使得在小鼠中精确量化WMC.

关键词:
鼠标 鼠标 鼠标 鼠标气味的味道 气味的味道工作记忆容量 工作记忆容量

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A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation

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A Free-breathing fMRI Method to Study Human Olfactory Function
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A Free-breathing fMRI Method to Study Human Olfactory Function

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相关实验视频

Last Updated: Jun 23, 2025

Olfactory Context Dependent Memory: Direct Presentation of Odorants
04:47

Olfactory Context Dependent Memory: Direct Presentation of Odorants

Published on: September 18, 2018

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A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation
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A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation

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A Free-breathing fMRI Method to Study Human Olfactory Function
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A Free-breathing fMRI Method to Study Human Olfactory Function

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科学领域:

  • 神经科学是一个神经科学.
  • 动物行为 动物行为

背景情况:

  • 工作记忆能力 (WMC) 是一个关键的认知功能.
  • 了解WMC的神经生物学是一个主要的研究重点.
  • 机械学研究需要WMC的动物模型.

研究的目的:

  • 介绍一种新的行为范式,即动物的嗅觉工作记忆能力 (OWMC) 任务.
  • 为实施OWMC范式提供详细指令.
  • 为了能够准确量化小鼠中的WMC.

主要方法:

  • OWMC范式包括五个阶段:上下文适应,挖掘训练,对单个样本气味不匹配的规则学习 (NMSS),对多个样本气味不匹配的规则学习 (NMMS) 和能力测试.
  • 小鼠习惯于环境,并接受了对气味区分任务的训练.
  • 通过WMC测试来评估性能,直到达到稳定的水平.

主要成果:

  • OWMC范式有效地训练小鼠进行基于气味的工作记忆任务.
  • 该协议允许对动物的WMC进行系统评估.
  • 稳定的性能水平表明WMC测量成功.

结论:

  • OWMC范式是评估动物工作记忆能力的验证工具.
  • 该协议促进了WMC在神经科学中的标准化研究.
  • OWMC任务为研究WMC的神经生物学基础开辟了新的途径.