在使用心室辅助器件的儿科患者中,营养状况和管感染
Mostafa Abbasi Dezfouly1, Aamir Jeewa2,3, Andrea Maurich2
1Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Artificial organs
|June 17, 2024
概括
使用心室辅助器械 (VAD) 的儿科患者在植入前体重,肌素和前白蛋白水平较高时,面临着管感染风险的增加. 感染者和非感染者之间营养不良状态没有显著差异.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 医疗器械技术 医疗器械技术
- 传染性疾病 传染性疾病
背景情况:
- 对于儿科心脏移植候选人来说,心室辅助器件 (VAD) 是非常重要的.
- 体VADs涉及管,可以成为感染的来源.
- 这项研究调查了儿科VAD患者的管感染,重点关注营养状况.
研究的目的:
- 检查儿科VAD患者管感染的发病率和危险因素.
- 评估营养状况在VAD管感染的发展中的作用.
主要方法:
- 对使用柏林心脏EXCOR® VAD (2005-2021) 的儿科患者 (20岁以下) 的回顾性研究.
- 通过阳性培养和抗生素治疗定义的管感染.
- 使用A.S.P.E.N.进行评估的营养不良. 这些指导方针和密歇根MTool.
主要成果:
- 超过四分之一 (26.3%) 的患者患有管感染.
- 更高的植入前体重,肌素和前白蛋白与感染率的增加有关.
- 较长时间的VAD支持也与更高的感染风险相关.
结论:
- 特定的植入前临床和实验室标记与管感染风险的增加有关.
- 在这项研究中定义的营养状况并没有区分感染者与未感染者.
- 需要在更大的队列中进行进一步的研究,以验证研究结果并探索预测性营养措施.
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