在糖尿病前期,高灵敏度的托波T与左心室功能障碍的相关性
Okan Tanriverdi1, Lutfu Askin2
1Department of Cardiology, Siirt Education and Research Hospital, Siirt, Turkey.
Acta cardiologica
|June 17, 2024
概括
糖尿病前期患者表现出高灵敏性心脏托素T (hs-cTnT) 水平的升高,表明心肌损伤的亚临床. 这项研究将较高的hs-cTnT与糖尿病前期左心室缩和放缩功能障碍相关联.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 生物标志物 生物标志物
背景情况:
- 葡萄糖耐受性损害 (IGT) 和禁食葡萄糖损害 (IFG) 是全球越来越多的健康问题.
- 在糖尿病前期患者中,心血管疾病 (CVD) 风险较高.
- 在糖尿病前期的亚临床心肌损伤可以通过高灵敏度的心脏托素T (hs-cTnT) 检测.
研究的目的:
- 研究糖尿病前期患者的左心室 (LV) 功能和hs-cTnT水平之间的关联.
- 为了确定hs-cTnT是否可以预测糖尿病前期的亚临床LV功能障碍.
主要方法:
- 预期招募96名糖尿病前期患者和96名匹配的健康对照.
- 使用组织多普勒成像 (TDI) 评估 LV 缩和腹功能.
- 在糖尿病前期和对照组之间测量和比较hs-cTnT水平.
主要成果:
- 与对照组相比,糖尿病前患者的MAPSE,E,E/Em和Sm值显著更高 (p < .001).
- Hs-cTnT被确定为左心室扩张性功能障碍 (LVDD) (OR=2.625,p < .001) 和收缩性功能障碍 (LVSD) (OR=1.922,p = .004) 的独立预测因子.
结论:
- 糖尿病前患者的hs-cTnT水平比健康对照人高.
- 在糖尿病前期患者中,LVSD和LVDD有负面影响.
- 升高的hs-cTnT水平可能与糖尿病前期的亚临床左心室功能障碍相关.
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