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Updated: Jun 23, 2025

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使用第一剂后估计的AUC优化polymyxin B剂量的三种方法:与蒙特卡洛模拟生成的数据进行验证

Qingxia Liu1,2, Jianxing Zhou1,2, You Zheng1,2

  • 1School of Pharmacy, Fujian Medical University, Fuzhou, China.

Xenobiotica; the fate of foreign compounds in biological systems
|June 17, 2024
PubMed
概括

三种方法用有限的第一剂量度来估计稳定状态下曲线下的polymyxin B面积 (AUC). 这些方法,特别是四点方法,为优化多素B剂量方案提供了准确的估计.

关键词:
蒙特卡洛模拟的蒙特卡洛模拟波利米克辛B是一种多重的物质.剂量优化剂量优化药理动力学/药理动力学人口的药理动力学

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