作为一种对pH值敏感的药物递送系统,逐层研究基多-德克斯特兰硫酸盐涂层的中孔二氧化
Mohammad Reza Hooshyar1, Shahram Raygan2, Rouhollah Mehdinavaz Aghdam3
1Synthesis and Extraction of Materials Lab., School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, P.O. Box 11155-4563, Tehran, Iran. mohammadreza.hooshyar14@gmail.com.
Journal of materials science. Materials in medicine
|June 17, 2024
概括
基托-德克斯硫酸盐涂层的中孔性纳米颗粒显示出药物传递的潜力,改善细胞活力,并为动脉样硬化治疗提供pH敏感的罗斯瓦斯塔丁释放.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 用素 (CS) 涂覆的半孔性纳米粒子 (MSNP) 是有前途的药物载体.
- 为MSNP-CS优化含药复合体对于细胞活力,药物释放和动脉样硬化预防至关重要.
- CS和硫酸 (DX) 的多电解质复合物 (PEC) 为药物输送提供了有利的生物特性.
研究的目的:
- 合成和评估MSNPs涂有CS-DX (MSNPs-CS-DX) 作为药物输送系统.
- 评估使用MSNPs-CS-DX.Rosuvastatin的封装和释放动力学.
- 在动脉样硬化背景下研究MSNPs-CS-DX的生物相容性和潜在的治疗效用.
主要方法:
- 使用简单的涂层工艺合成MSNP-CS-DX.
- 使用FTIR,FESEM,TEM和DLS进行MSNP-CS-DX的表征.
- 通过BET分析评估颗粒大小,层厚度,孔径大小和孔隙性.
- 评估药物捕获效率和pH敏感药物释放动力学.
- 使用人类静脉内皮细胞 (HUVEC) 进行细胞活性的体外评估.
主要成果:
- 通过光谱和显微镜分析证实MSNPs-CS-DX的成功形成.
- 平均粒子大小为110nm,CS-DX层厚度为10-15nm.
- 罗斯瓦斯塔丁的高捕获效率为57%.
- 证明了pH敏感的药物释放动力学.
- 与未涂层的MSNP相比,显著提高HUVEC细胞活力 (在24小时内约24%) .
- CS-DX层显示出阻碍巨细胞吸收低密度脂蛋白 (LDL) 的潜力.
结论:
- MSNPs-CS-DX作为一个有效和生物相容的药物载体系统.
- CS-DX涂层的pH敏感性允许控制药物释放.
- 这种系统通过输送Rosuvastatin,证明了增强的细胞活力和动脉样硬化治疗的潜力.
- 阻止LDL吸收的能力进一步增强了MSNPs-CS-DX的治疗潜力.
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