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从人类肠道微生物分离物中识别avaC,该分离物将5AVA转化为2-Piperidone

Qiudi Zhou1, Lihui Feng2

  • 1Institute of Pediatrics, Children's Hospital of Fudan University, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, People's Republic of China.

Journal of microbiology (Seoul, Korea)
|June 17, 2024
PubMed
概括

研究人员确定了四种肠道细菌株,这些细菌株从5-氨基瓦勒酸 (5AVA) 中产生2-piperidone. 酶avaC被确定为负责尼龙生物合成中的这一关键步骤.

关键词:
avaC (5-氨基瓦烯酸循环酶) 是一种5-氨基瓦烯酸循环酶.2 - 皮皮里二烯的使用.交叉养是一种交叉养.肠道微生物群的新陈代谢

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Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...
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