梅佩里丁与吗啡相比,用于与单克隆抗体相关的输液反应相关的严格性
Hanna Yakubi1, Aaron Paul Steele1, Megan Tsao1
1Department of Pharmacy, University of California at Davis Health System, Sacramento, CA, USA.
概括
吗啡和梅佩里丁都有效地治疗单克隆抗体 (MAB) 治疗期间的硬度. 吗啡为管理输液反应提供了一种安全和可行的替代梅佩里丁.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 在单克隆抗体 (MAB) 治疗期间,输液反应,包括硬度,发烧和低血压是常见的.
- 尽管证据有限,阿片类药物,特别是美丁,经常用于MAB相关的严格性.
- 需要比较不同类阿片类药物的有效性和安全性,以应对与MAB相关的严格性.
研究的目的:
- 为了比较静脉注射 (IV) 梅佩里丁与吗啡在治疗MAB相关硬度方面的疗效和安全性.
- 评估严格除所需的阿片类药物剂量数量.
- 评估二次结果,如纳洛的使用率和镇静率.
主要方法:
- 一个单一的中心,回顾性队列研究.
- 包括从2015年1月到2024年1月接受IV2毫克吗啡或25毫克美佩里丁用于MAB相关的严格的患者.
- 主要结局:阿片类药物剂量用于严格除;二次结局:纳洛率和镇静.
主要成果:
- 分析了127种美里丁和26种吗啡强度事件.
- 两组中的大多数人只需要一种阿片类药物剂量来进行严格的废除 (p=0.539).
- 在美佩里丁和吗啡队伍中观察到低镇静率.
结论:
- 梅佩里丁和吗啡都有效地管理MAB相关的严格性,安全问题最小.
- 吗啡在与MAB相关的严格性方面,是梅佩里丁的合适替代品.
- 研究结果可能会为制定药物决定提供信息,解决药物短缺问题,并优化MAB治疗中的支持性护理.
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