孕妇高血压和后代患病风险:一个纵向队列研究
Nathalie Auger1,2,3,4, Banmeet Padda5, Philippe Bégin5,6,7
1University of Montreal Hospital Research Centre, Montreal, QC, Canada. nathalie.auger@inspq.qc.ca.
European journal of pediatrics
|June 17, 2024
概括
孕产妇的妊娠激增 (HG) 增加了儿童住院的风险. 暴露于HG的儿童患上神经,发育,消化和过敏等疾病的住院率较高.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 流行病学 流行病学
背景情况:
- 妊娠中症 (HG) 与后代的神经发育问题有关,但其对其他儿童疾病的影响尚不清楚.
- 这项研究调查了母亲的HG与更广泛的儿童健康结果之间的关联.
研究的目的:
- 检查母亲的孕妇高血压和儿童患病率住院的风险之间的关联.
- 为了确定母亲的HG是否会影响儿童的长期健康结果.
主要方法:
- 一项对1,189,000名出生于加拿大北克的儿童进行的纵向队列研究 (2006-2021年).
- 暴露被定义为孕产妇的妊娠过度,需要在妊娠的第一或第二个三个月住院治疗.
- 结果被评估为使用Cox回归模型分析的16岁以下任何儿科住院.
主要成果:
- 孕产妇的妊娠高血流与16岁之前入院的风险增加了1.21倍.
- 对神经系统 (HR 1.50),发育 (HR 1.51),消化系统 (HR 1.40) 和过敏性疾病 (HR 1.39) 进行住院治疗的风险增加.
- 与孕产妇前相比,重症性高血压是这些结果的一个更强大的危险因素.
结论:
- 孕产妇的孕妇高血压与儿童住院的风险增加有关.
- 这种关联在神经,发育,消化和亚托皮性疾病中尤为显著.
- 这些发现凸显了HG对后代的潜在长期健康影响.
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