硫化通过降低矩阵金属蛋白酶-9的调节来改善心脏衰老
Kaichuan He1, Huaxing Zhang2, Bo Tan3
1Department of Physiology, Hebei Medical University, 050017, Hebei, China.
Cardiovascular drugs and therapy
|June 17, 2024
概括
补充硫化 (H2S) 通过减少矩阵金属蛋白酶-9 (MMP-9) 和改善心脏功能来对抗与年龄有关的心脏衰退. 这项研究表明,H2S在衰老期间保持心脏结构和功能.
科学领域:
- 心血管科学 心血管科学
- 衰老研究研究 衰老研究
- 生物化学 生物化学
背景情况:
- 衰老是心血管疾病的主要危险因素,其特点是心脏中的矩阵金属蛋白酶-9 (MMP-9) 的增加和硫化 (H2S) 的减少.
- 与年龄相关的心脏功能障碍包括扩张功能受损,纤维化和结构变化.
研究的目的:
- 调查外源H2S补充能否抵消与年龄相关的心脏衰退.
- 为了确定H2S对心脏H2S水平的影响,MMP-9表达,以及老化中的心脏形态和功能.
主要方法:
- 对与人类年龄相关的血H2S和MMP-9水平的分析.
- 给老年小鼠注射硫化物 (NaHS) 并评估心脏功能,结构,纤维化和分子标志物 (MMP-9,CSE).
- 使用小干扰RNA进行体外研究,以阐明MMP-9和cystathionine gamma-lyase (CSE) 之间的关系.
主要成果:
- 在人体中,血H2S水平下降,而MMP-9水平随着年龄的增长而增加.
- 老年小鼠表现出心脏H2S降低,腹功能受损,心脏纤维化增加.
- 在老年小鼠中补充H2S改善了心脏功能,结构,并减少了纤维化和MMP-9表达.
结论:
- 硫化 (H2S) 在衰老的心脏中起着保护作用.
- 在衰老过程中,H2S维持心脏结构和功能,部分是通过抑制MMP-9表达来实现.
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