抗高血压和风险的 ангиотензин受体阻塞剂
Xuerong Wen1, Marianne N Otoo1, Jie Tang2
1Department of Pharmacy Practice and Clinical Research, College of Pharmacy, University of Rhode Island, Kingston.
JAMA neurology
|June 17, 2024
概括
ангиотензин受体阻断剂 (ARBs) 与美国成年人的其他血压药物相比,与风险降低有关. 这一发现,特别是洛萨坦,表明ARB在高血压管理中的潜在抗性质.
科学领域:
- 心血管医学 心血管医学
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 之前的研究表明,血管激素受体抑制剂 (ARB) 与其他抗高血压药物相比,可能降低风险.
- 来自美国的观察数据,专门研究这种关联是有限的.
研究的目的:
- 评估ARB使用与美国高血压患者发病率之间的关联.
- 为了比较ARB使用者与其他主要抗高血压类别之间的风险.
主要方法:
- 使用国家卫生行政数据库 (2010-2017年) 进行回顾性队列研究.
- 倾向性得分匹配被用来比较ARB使用者与使用血管激素转化酶抑制剂 (ACEI),β阻断剂 (β阻断剂) 或通道阻断剂 (CCB) 的用户.
- 考克斯回归分析评估了随访期间发病率.
主要成果:
- 该研究包括超过220万名高血压患者,倾向性得分匹配,创建可比较的子组.
- 与ACEI (aHR,0.75),β阻断剂 (aHR,0.70) 和CCB (aHR,0.72) 相比,ARB使用与发病率显著降低.
- 亚组分析表明,特定的ARB洛萨坦与较低的发病率有显著的关联,特别是在以前没有中风或心血管疾病的患者中.
结论:
- 血管激素受体阻断剂 (ARBs),尤其是洛沙坦,与其他抗高血压药物相比,与高血压患者的发病率降低有关.
- 这些发现表明ARBs具有潜在的抗性质,特别是在没有先前心血管疾病的个体中.
- 建议进行进一步的研究,包括随机临床试验,以证实这些比较性抗原效应.
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