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代谢综合征中的结构性大脑变化:对皮下和相关结构的全面MRI体积分析

Hatice Cakir¹, Mukadder Sunar¹, Sonay Aydın²

¹Department of Anatomy, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey.

Metabolic syndrome and related disorders

|June 17, 2024

概括

代谢综合征 (MetS) 在皮下区域显著减少大脑体积,包括黑色物质和体. 这些神经解剖学变化突出显示了对认知功能的潜在影响.

科学领域:

神经成像是一种神经成像.
神经科学是一个神经科学.
放射学放射学是一门学科.

背景情况:

代谢综合征 (MetS) 是一组增加心血管风险的疾病.
对于MetS对皮下大脑结构的神经解剖学后果仍然不完全理解.

研究的目的:

通过使用高分辨率的MRI来研究MetS对皮下大脑结构体积的影响.
探索MetS的神经解剖学基础及其潜在的认知影响.

主要方法:

与25名MetS患者和15名对照进行的横截面研究.
高分辨率MRI (1.5T西门子Aera) 和MRICloud平台用于体积分析.
脑皮下脑区和相关结构的定量评估.

主要成果:

患有MetS的个体在所有测量的皮质下大脑区域 (P <0.05) 中显示出显著的体积减少.
关键受影响的区域包括黑质体,体和乳头.
最大的体积差异在基底格里亚 (L: 1322.4 mm3);最显著的百分比差异在黑色物质 (R: 25.24%) 和尾状核 (L: 21.02%).

结论:

MetS与显著的神经解剖学变化有关,特别是关键的皮层下大脑区域的体积减少.
这些发现表明MetS和改变的大脑结构之间的联系,可能会影响认知功能.
需要进一步的研究,以了解MetS对认知的全面影响,并探索早期干预措施.

关键词:

大脑绘制地图大脑体积的大脑体积代谢综合征代谢综合征神经成像是一种神经成像.下皮层结构的下皮层结构.

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