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Updated: Jun 25, 2026

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单细胞分析确定PLK1是LUAD中免疫抑制瘤微环境的驱动因素

Yifan Kong1, Chaohao Li1, Jinpeng Liu2

  • 1Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, United States of America.

PLoS genetics
|June 17, 2024
PubMed
概括

波罗样酶1 (PLK1) 通过促进M2巨细胞极化和阻碍抗原呈现,影响免疫疗法的有效性,驱动肺腺癌中的免疫抑制性瘤微环境.

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Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...