评估光生物调制在经受冲击的第三下部提取术后期的预防效果:一个随机的,受控的,双盲研究协议
Daniel Rodríguez Salaberry1,2, Laura Hermida Bruno1,2, Rolf Wilhem Consolandich Cirisola1,2
1Postgraduate Program in Biophotonics Medicine, Nove de Julho University, Sao Paulo, Sao Paulo, Brazil.
PloS one
|June 17, 2024
概括
预防性光生物调制可以有效地减少第三手术后的胀和疼痛. 这项研究调查了在手术前其潜在的益处,以改善患者的治疗结果.
科学领域:
- 口腔和牙面部外科手术
- 生物医学工程 生物医学工程
- 疼痛管理 疼痛管理
背景情况:
- 光生物调制 (PBM) 已被公认为用于治疗术后疼痛,和.
- 在第三手术前PBM的应用仍未得到充分研究.
- 受影响的第三底骨提取通常会导致显著的术后后果.
研究的目的:
- 评估预防性光生物调节在缓解术后的疗效.
- 评估预防性PBM对疼痛,三,消和止痛药消费的影响.
- 为了比较对照组 (皮质类固醇 + 假 PBM) 和 PBM 组 (激光 + LED) 之间的结果.
主要方法:
- 随机对照试验涉及健康个体接受受影响的第三骨下部提取.
- 光生物调节组:在外科手术前内口低强度激光和外口LED集群应用.
- 对照组:预防性皮质类固醇和模拟光生物调节.
- 结果 (,疼痛,三,消化不良,止痛药摄入量) 在基线,手术后2天和7天评估.
主要成果:
- 主要结局:在48小时后出现术后.
- 二次结局:疼痛,三,消化不良,并服用类药物.
- 不良影响将被系统地记录下来.
- 统计学意义是通过p值<0.05来确定的.
结论:
- 预防性光生物调制为管理第三手术并发症提供了一种新的方法.
- 需要进一步的研究,以建立最佳的PBM协议,以预防性使用.
- 这项研究旨在提供证据,证明PBM是口腔手术恢复的宝贵辅助.
相关概念视频
02:07Blind Procedures
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...
01:11Blinding
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.