在老年人处方干预:系统性审查的概述
Shiyun Chua1, Adam Todd2,3, Emily Reeve4,5
1School of Public Health, University of Washington, Seattle, Washington, United States of America.
PloS one
|June 17, 2024
概括
在老年人中,降低处方干预措施有望减少药物使用,但对其他结果和弱势群体缺乏强有力的证据. 需要更多的研究来评估危害和患者报告的影响.
科学领域:
- 老年学是指老年学的学科.
- 药理学 药理学是指药理学的学科.
- 证据综合 证据综合
背景情况:
- 抑郁症描述领域面临的挑战是由于缺乏共识和知识差距.
- 老年人经常管理多种药物,增加药物不良事件的风险.
研究的目的:
- 通过对系统性审查进行概述,总结有关老年人抑郁症治疗干预措施的现有证据.
- 确定有关有效性和安全性的证据中的差距.
主要方法:
- 从2005年1月到2023年3月,对11个数据库进行了全面搜索,以确定相关的系统审查.
- 包含的评论被合成成两个步骤:总结报告的结果,并进行结果的叙事综合.
- 通过使用A MeaSurement Tool to Assess Systematic Reviews 2 (AMSTAR 2) 工具进行了包含的审查的质量评估.
主要成果:
- 分析包括了48个系统性审查,包括17个元分析.
- 降低处方干预表明药物减少的证据,但对其他结果 (如不良事件) 的影响是混合的或有限的.
- 对于特定易受伤害的子组,如痴呆症,虚弱或多病症患者,数据有限.
结论:
- 降低处方干预措施在老年人减少药物服用方面似乎有效.
- 需要更多高质量的研究,特别关注不良事件,患者报告的结果和弱势群体.
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