人类的生殖腺不会对11氧化雄激素的循环池做出贡献
Suranut Charoensri1,2, Juilee Rege3, Chaelin Lee1
1Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
The Journal of clinical endocrinology and metabolism
|June 17, 2024
概括
人类的生殖腺产生androstenedione (A4) 和 (T),但没有大量的11-氧化 (11-oxyandrogens). 这项研究澄清了淋巴体对循环11-oxyandrogens的贡献.
科学领域:
- 内分泌学 在内分泌学.
- 类固醇的产生.
- 生殖生物学 生殖生物学
背景情况:
- 安德二 (A4) 和 (T) 是由上腺和性腺产生的关键雌激素.
- 酶11β-基酶 (CYP11B1) 合成来自A4和T的11-氧化 (11-oxyandrogens).
- 循环中的11-oxyandrogen水平在男性和女性中相似,尽管T水平不同,这表明淋巴腺参与有限.
研究的目的:
- 为了确定淋巴体对11-oxyandrogens循环池的贡献程度.
- 为了研究 gonadal 组织中关键的类固醇酶的表达.
主要方法:
- 液体染色学-并联质谱法用于量化13种类固醇,包括11-oxyandrogens,在配对的淋巴腺和外围静脉血液样本中.
- 在双边salpingo-oophorectomy (BSO) 之前和之后,在女性中测量了类固醇水平.
- 对CYP11B1,CYP17A1和HSD3B2的mRNA表达在上腺,卵巢和丸组织中进行了比较.
主要成果:
- 与外围静脉相比,阴道静脉显示出A4,T和其他传统类固醇的水平较高 (P < .05).
- 四种11-oxyandrogens在匹配的淋巴腺和外周静脉样本中显示出类似的度.
- 在BSO之后,A4和T水平显著下降,而11-oxyandrogen水平保持稳定;淋巴细胞组织的CYP11B1mRNA表达值得忽略.
结论:
- 人的生殖腺产生大量的A4和T.
- 尽管有A4和T的产生,人类的生殖腺并不是循环11-oxyandrogens的重要来源.
- 上腺可能是循环11-oxyandrogens的主要来源.
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