瘤性calreticulin通过刺激TGFβ表达和骨髓微环境中的调节性T细胞扩张来诱导免疫逃生

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Updated: Jun 23, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Published on: October 27, 2020

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Dominik Schmidt1,2, Cornelia Endres1,2, Rouven Hoefflin3

  • 1Department of Medicine I - Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Cancer research
|June 17, 2024
PubMed
概括

向突变性calreticulin (CALR) 和TGFβ1途径在骨髓增殖性瘤 (MPN) 中可以增强T细胞活性. 这种方法可以打击免疫逃逸,并为MPN患者提供新的治疗策略.

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