在皮质基底综合征中,PET和血生物标志物的关系
Neha Atulkumar Singh1, Alla Alnobani2, Jonathan Graff-Radford1
1Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
概括
化陶 (p-tau) 181和状纤维酸蛋白 (GFAP) 的等离子体生物标志物可以帮助检测皮质基底综合征 (CBS) 中的阿尔茨海默病 (AD). 神经纤维光 (NfL) 可能表明CBS,无论AD病理.
科学领域:
- 神经学 神经学
- 生物标志物发现发现
- 神经退行性疾病 神经退行性疾病
背景情况:
- 皮层骨干综合征 (CBS) 可能与阿尔茨海默病 (AD) 病理有关.
- 血生物标志物对预测CBS患者AD的实用性在很大程度上是未知的.
- 定子发射断层扫描 (PET) 是确认AD生物标志物的关键工具.
研究的目的:
- 研究血生物标志物的有效性,以识别患有CBS的个体的AD病理.
- 为了比较CBS患者的血生物标志物度,其中有和没有粉样β (Aβ) 阳性.
- 探索血生物标志物与PET成像结果之间的相关性.
主要方法:
- 一组由18名CBS患者 (8名Aβ+,10名Aβ-) 和8名认知不受损 (CU) 控制组组成的队列接受了PET成像和血分析.
- 用统计测试 (克鲁斯卡尔-瓦利斯) 分析和比较血度.
- 使用斯皮尔曼相关性来评估血生物标志物和PET吸收之间的关系.
主要成果:
- 患有Aβ+病理的CBS患者显示Aβ42 / 40比率降低,血酸化tau (p-tau) 181升高,状纤维酸蛋白 (GFAP) 和神经纤维光 (NfL).
- 与对照组相比,Aβ-病理的CBS患者的NfL度较高.
- 血p-tau181和GFAP水平在CBS Aβ-和CBS Aβ+组之间进行了区分,并与Aβ和tau PET吸收呈正相关.
结论:
- 血p-tau181和GFAP是检测CBS患者AD的有价值的生物标志物.
- 血NfL可以作为CBS的一般生物标志物,无论底层的AD病理.
- 这些发现突出了基于血液的生物标志物的潜力,以改善CBS的诊断和管理.
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