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Updated: Jun 23, 2025

Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy
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Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy

Published on: September 12, 2019

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透视微塑料和人类α-Synuclein蛋白之间的结合相互作用,通过多光谱检测和氨基原性寡合体形成

Souvik Ghosal1, Sagar Bag2, Sudipta Bhowmik1,2

  • 1Mahatma Gandhi Medical Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), Pondy-Cuddalore Main Road, Pillaiyarkuppam, Pondicherry 607402, India.

The journal of physical chemistry letters
|June 17, 2024
PubMed
概括

微塑料,包括聚烯微塑料 (PS-MPs),可以促进人类α-synuclein蛋白的聚合,这是帕金森病的关键因素. 这种结合改变了蛋白质结构,加速了与疾病相关的变化.

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相关概念视频

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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