Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Blood-brain Barrier00:49

The Blood-brain Barrier

Overview

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Rationale and current status of fecal microbiota transplantations for Parkinson's disease.

Journal of Parkinson's disease·2026
Same author

Experience shapes the transformation of olfactory representations along the cortico-hippocampal pathway.

eLife·2026
Same author

High-Affinity Nanobody Against the LEDGF PWWP Domain Inhibits Chromatin Binding In Vitro.

Biomolecules·2026
Same author

Ferroptosis-armed dendritic cell vaccines for glioma immunotherapy.

Nature communications·2026
Same author

Systemic Inflammation Modulates Clearance and Drives Extra-Hepatic Distribution of Extracellular Vesicles.

Journal of extracellular vesicles·2026
Same author

Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Electroactive Sodium Alginate-Based Hydrogel Textile for Synergistic Antibacterial and Regenerative Therapy in Diabetic Wound.

Advanced healthcare materials·2026
Same journal

Microfluidic Biofabrication of a Hydrogel Vessel-Like Structure for Interrogating Tumor Cell Propagation in a Breast Cancer-on-a-Chip Model.

Advanced healthcare materials·2026
Same journal

Hydrogel-Based Systems in Intrauterine Adhesions: Bridging the Gap from Bench to Bedside.

Advanced healthcare materials·2026
Same journal

A Muscle-Mimetic Core-Sheath Composite Yarn Scaffold for In-Body Tissue Induction and Regeneration of Small-Diameter Vascular Grafts.

Advanced healthcare materials·2026
Same journal

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden.

Advanced healthcare materials·2026
Same journal

Therapeutic Extracellular Vesicles from Synovial Fibroblast-Primed MSCs for Osteoarthritis Treatment.

Advanced healthcare materials·2026
查看所有相关文章

相关实验视频

Updated: May 31, 2026

Applying Microfluidics to Electrophysiology
05:41

Applying Microfluidics to Electrophysiology

Published on: October 1, 2007

9.4K

微流体接口为长期双向访问大脑.

Simone Marcigaglia1,2, Robin De Plus1,2, Charysse Vandendriessche3,4

  • 1Neuroelectronics Research Flanders (NERF), Leuven, 3000, Belgium.

Advanced healthcare materials
|June 17, 2024
PubMed
概括
此摘要是机器生成的。

在研究模型中,双光子聚合制造了微导管,用于精确的脑药物输送和脑脊液采样. 这项技术为慢性神经学研究和潜在生物标志物跟踪提供了一种不那么破坏性的方法.

关键词:
脑部疾病 脑部疾病大脑脊髓液中的脑脊液.通过对流增强交付的交付.液体活检活检液体活检

更多相关视频

Brain Slice Stimulation Using a Microfluidic Network and Standard Perfusion Chamber
27:58

Brain Slice Stimulation Using a Microfluidic Network and Standard Perfusion Chamber

Published on: October 1, 2007

10.9K
BioMEMS: Forging New Collaborations Between Biologists and Engineers
07:26

BioMEMS: Forging New Collaborations Between Biologists and Engineers

Published on: November 1, 2007

8.1K

相关实验视频

Last Updated: May 31, 2026

Applying Microfluidics to Electrophysiology
05:41

Applying Microfluidics to Electrophysiology

Published on: October 1, 2007

9.4K
Brain Slice Stimulation Using a Microfluidic Network and Standard Perfusion Chamber
27:58

Brain Slice Stimulation Using a Microfluidic Network and Standard Perfusion Chamber

Published on: October 1, 2007

10.9K
BioMEMS: Forging New Collaborations Between Biologists and Engineers
07:26

BioMEMS: Forging New Collaborations Between Biologists and Engineers

Published on: November 1, 2007

8.1K

科学领域:

  • 生物医学工程 生物医学工程
  • 神经科学是一个神经科学.
  • 添加剂制造 添加剂制造 添加剂制造

背景情况:

  • 双光子聚合 (TPP) 是一种高分辨率的增材制造技术.
  • 生物相容和非细胞毒性树脂对于生物医学应用至关重要.
  • 临床前研究需要慢性流体进入大脑.

研究的目的:

  • 开发使用TPP的微流体接口,用于脑药物输送和脑脊液 (CSF) 取样.
  • 在临床前模型中评估这些微导管的性能.
  • 评估同时药物输送和生物标志物跟踪的潜力.

主要方法:

  • 使用两光子聚合制造微导管接口.
  • 在脑幻体和小鼠中测试了微导管输液.
  • 在体内250天内评估的纵向脊髓样本采集.
  • 评估了血液-中枢神经液屏障的完整性和样品适合分子分析.

主要成果:

  • 与对照组相比,微导管可以实现更局部的药物分发,并减少回流.
  • 在体内注射更快,更精确,更少的破坏性.
  • 纵向骨骨抽样成功进行了长达250天的时间.
  • 血液-中枢神经液屏障保持完好,中枢神经液样本适用于生物标志物分析.

结论:

  • TPP是一种多功能技术,用于为大脑创建微流体接口.
  • 这些接口在临床前模型中促进了精确的药物输送和慢性CSF采样.
  • 该技术在神经疾病研究和治疗方面具有显著的翻译潜力.