在墨西哥儿童中,产前暴露于酸盐及其混合物与肺功能之间的关联

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Cheng-Yang Hu¹, Cecilia S Alcala², Hector Lamadrid-Figueroa³

¹Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1057, New York, NY 10029, USA; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, China.

Journal of hazardous materials

|June 17, 2024

概括

产前暴露于甲酸盐对儿童肺功能的影响在男孩和女孩中不同. 怀孕期间甲酸盐水平较高与女性肺功能更好,男性肺功能较差有关.

科学领域:

环境健康环境健康
儿科肺病学儿科肺病学
毒理学毒理学毒理学

背景情况:

早期的甲酸盐暴露与呼吸系统问题有关,但产前暴露对儿童肺功能的影响尚不清楚.
很少有研究研究过甲酸盐混合物或与肺功能的性别特异关联.
了解这些关系对于公共卫生干预至关重要.

研究的目的:

调查产前甲酸盐混合物与儿童肺功能之间的性别特定关联.
为了分析在不同怀孕季度暴露于甲酸盐的影响.
探索酸盐对肺部发育影响的潜在性别差异.

主要方法:

利用墨西哥的PROGRESS队列 (N=476) 与第二和第三季度的母亲尿液样本.
评估8至13岁儿童的肺功能 (FEV1,FVC).
采用多变量线性回归,WQS回归和分层BKMR,按性别分层.

主要成果:

对于第二个三个月的甲酸盐混合物暴露和肺功能 (FEV1,FVC z-score) 发现了显著的性别相互作用.
较高的第二季度甲酸盐暴露与女性FEV1和FVCz-score的增加相关.
相反,在男性中,更高的第二季度甲酸盐暴露与FEV1和FVCz-score降低有关.

结论:

产前甲酸盐暴露与儿童肺功能有关,以性别特定的方式.
这些发现强调了在环境健康研究中将性别视为生物变量的重要性.
这项研究提供了针对针对性公共卫生战略的证据,以应对甲酸盐暴露风险.

关键词:

儿童健康儿童健康肺功能肺功能肺功能混合物暴露混合物暴露甲酸的含量甲酸的含量

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