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多发性硬化症患者的认知表现和磁共振成像:系统性审查和元分析
Omid Mirmosayyeb1, Fardin Nabizadeh2, Elham Moases Ghaffary3
1Department of Neurology, Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States.
Multiple sclerosis and related disorders
|June 17, 2024
概括
乳头体积与多发性硬化症 (pwMS) 患者的处理速度和记忆等认知功能密切相关. 本综述综合了pwMS中MRI测量和认知测试之间的关键相关性.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 临床神经学 临床神经学
背景情况:
- 认知障碍在多发性硬化症 (MS) 中很常见.
- 结构磁共振成像 (MRI) 揭示了MS (pwMS) 患者的大脑变化.
- 在pwMS中,特定的MRI指标和认知测试表现之间的准确关系仍在争论中.
研究的目的:
- 系统地审查和综合MRI测量和pwMS认知功能之间的相关性.
- 为了确定大脑结构和认知表现之间的最一致的关联.
主要方法:
- 在PubMed/MEDLINE,Embase,Scopus和Web of Science数据库中进行了系统的搜索,直到2023年2月.
- 搜索术语包括认知性能测试和MRI测量与pwMS相关.
- 在R软件中使用随机效应模型估计了聚合效应大小.
主要成果:
- 从一项对13,559项研究的初步审查中,包括了136项研究.
- 塔拉米体积与符号数字模式测试 (SDMT),简要视觉记忆测试-修订-总回忆 (BVMT-TR),加利福尼亚语言学习测试-II-总回忆 (CVLT-TR) 和德利斯-卡普兰执行功能系统 (DKEFS) 有显著的相关性.
- 对于这些关联,报告了特定的相关系数 (r) 和置信区间.
结论:
- 胸膜体积与信息处理速度,视觉空间学习记忆,口头学习记忆和pwMS中的执行功能显著相关.
- 这些发现凸显了体完整性对MS认知健康的重要性.
- 需要进一步的研究,以充分阐明这种关系的潜在机制.
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