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Updated: Jun 23, 2025

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使用动态共价化学进行长期局部麻醉的聚合原药

Tianrui Xue1, Yang Li1, Matthew Torre2

  • 1Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, 02115, United States.

Angewandte Chemie (International ed. in English)
|June 17, 2024
PubMed
概括

这项研究开发了一种新的前药物策略,使用动态共价化学来持续药物输送. 新方法有效降低了四毒素 (TTX) 毒性和延长了神经阻塞持续时间.

关键词:
药物交付是药物交付的过程.动态的共价化学局部麻醉局部麻醉聚合物前药物 聚合物前药物类毒素 (tetrodotoxin) 是一种有毒的毒素.

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