时间是NTCP:我们应该最大限度地提高患者的吞吐量,还是对质子疗法系统进行在线适应?
E Borderías-Villarroel1, A Barragán-Montero1, E Sterpin2
1UCLouvain, Institut de recherche expérimentale et clinique, Molecular Imaging and Radiation Oncology (MIRO) Laboratory, Brussels, Belgium.
概括
质子疗法 (PT) 提供了比传统放射治疗 (XT) 更好的正常组织并发症概率 (NTCP). 然而,为了保持PT的PT.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 与传统放射治疗 (XT) 相比,质子疗法 (PT) 可能会改善正常组织并发症概率 (NTCP).
- PT对解剖学变化的敏感性增加,需要更高的适应率,可能会降低患者的吞吐量.
- 在线适应策略可以减轻问题,但需要额外的重新规划时间,影响整体效率.
研究的目的:
- 作为适应时间的函数,研究患者吞吐量与PT中的NTCP收益之间的权衡.
- 为了确定在有限的机器容量范围内保持PT的治疗优势的最佳适应时间.
主要方法:
- 对14名肺癌患者进行了回顾性分析,并进行了重复的4DCT扫描.
- 在各种适应情景下,在XT和PT之间比较了NTCP2年死亡率,消化不良和肺炎的值.
- 患者的吞吐量是基于每天8小时的容量计算的,考虑到适应所需的时间.
主要成果:
- 在没有调整的情况下,PT对XT的基线NTCP收益从6.1%到7.7%不等.
- 随着即时在线调整和2毫米的设置错误,NTCP的收益增加到10.7%13.6%.
- 最多允许额外的13.7分钟的适应时间,以保持NTCP的好处在容量限制内.
结论:
- 简短的在线适应时间对于最大限度地发挥PT的好处至关重要,尤其是在有限的机器容量的情况下.
- 在临床实践中平衡适应时间和患者吞吐量对于实现PT在临床实践中的全部潜力至关重要.
- 优化适应方案可以提高PT的有效性和患者的结果.
更多相关视频
08:34Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
20.3K
07:57Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
Published on: March 24, 2022
2.8K
相关概念视频
01:30Pneumonia V: Nursing management and Prevention
4.2K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
4.2K
01:29Acute Respiratory Failure-V
768
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
768
01:26Enteral Nutrition I: Orogastric and Nasogastric Feeding
3.1K
Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
3.1K
01:15Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
2.0K
Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
2.0K
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
2.0K
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
2.0K
01:28Chronic Kidney Disease III: Interprofessional Care
679
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
679