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开发一个轨道震动的生物反应器,具有一个方形的容器壁,一个大圆形的孔

Mingwu Su¹, Yixian Ou¹, Jia Fu²

¹Guangdong Provincial Key Laboratory of Micro/Nano Optomechatronics Engineering, College of Mechatronics and Control Engineering, Shenzhen University, Nan-hai Ave 3688, Shenzhen, Guangdong 518060, China.

Journal of biotechnology

|June 17, 2024

概括

一个新型的方形坦克与一个大圆形 (STCC) 墙形用于轨道震动生物反应器 (OSRs) 显著提高混合和质量转移. 这种设计有望提高生物制药制造效率.

科学领域:

生物技术是生物技术.
化学工程是化学工程的重要组成部分.
生物工艺工程生物工艺工程

背景情况:

轨道震动生物反应器 (OSR) 在生物制药制造中至关重要.
船舶壁的形状对OSR中的混合和质量转移产生了重大影响.
目前的圆柱形OSR设计限制了混合效率.

研究的目的:

建议和评估OSR的新型墙形,以增强混合和质量转移.
为了比较一个方形坦克与一个大圆形 (STCC) OSR与传统的圆柱形设计的性能.
调查STCC设计的理论和实验上的好处.

主要方法:

使用了计算流体动力学 (CFD) 模拟.
进行了实验验证.
对比分析的重点是混合时间和在一致的功耗下氧气传输效率.

主要成果:

在STCC的墙形展示了卓越的理论混合和质量转移效率.
模拟和实验表明,与圆柱形相比,STCC的OSR中的混合和氧气转移更高.
STCC的设计有效地克服了传统圆柱形OSR的局限性.

结论:

新型STCC墙形为OSR技术提供了一个有前途的进步.
预计这种设计将提高生物制药生产的效率.
进一步应用STCC的OSR对该行业具有重大潜力.

关键词:

混合时间混合时间在OSR中,OSRs是OSR.转移氧气转移氧气.在这里,我们可以看到STCC和STCC.特定功率消耗的特定功率消耗.

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