在两个潜在的纵向队列中,风湿性关节炎和通过吸烟状态改变螺旋计的变化
Keigo Hayashi1, Gregory C McDermott1,2, Pierre-Antoine Juge1
1Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, Massachusetts, USA.
RMD open
|June 17, 2024
概括
风湿性关节炎 (RA) 患者吸烟的肺功能下降速度比非RA比较慢. 然而,在RA的从未吸烟者中,肺功能下降的速度更快.
科学领域:
- 肺部医学 肺部医学
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 类风湿性关节炎 (RA) 是一种全身性自身免疫性疾病,可影响多个器官,包括肺部.
- 肺部疾病是RA患者常见的并发症,其对随着时间的推移对肺功能的影响尚未完全理解.
研究的目的:
- 为了比较类风湿性关节炎 (RA) 患者与非RA患者之间的螺旋测量测量的纵向变化.
- 研究吸烟状况和阻塞性模式对RA患者肺功能下降的影响.
主要方法:
- 来自英国生物库和COPDGene队伍的纵向数据的分析.
- 在基线和随访 (5-7年) 测量出的螺旋计 (FEV1%和FVC%).
- 多变量线性回归比较RA患者和非RA比较者,按吸烟状况和阻塞性模式分层 (FEV1/FVC <0.7).
主要成果:
- 在没有阻塞性模式的从未吸烟者中,RA与更大的FEV1%的下降有关 (β=-0.49,p=0.04).
- 在RA常吸烟者 (≥10包年) 中,FEV1%的下降幅度明显低于非RA比较者 (β=0.50,p=0.02),特别是在阻塞性模式 (β=1.12,p=0.01) 的患者中.
- 在FEV1/FVC下降方面也观察到类似的趋势;在FVC%变化方面没有发现显著差异.
结论:
- 患有RA的吸烟者,特别是具有阻塞性模式的吸烟者,比非RA的比较者表现出较慢的肺功能下降.
- 与非RA比较者相比,RA的从未吸烟者表现出加速的肺功能下降.
- 需要进行进一步的研究,以探索吸烟的RA患者中阻塞性肺病的治疗方法和病原性.
相关概念视频
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:20COPD: Pathogenesis and Clinical Features
258
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
258
01:22Chronic Obstructive Pulmonary Disease
1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:26Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
01:26COPD: Management Using Bronchodilators and Corticosteroids
195
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
195