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Updated: Jun 23, 2025

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通过N-终端修饰来进行治疗药物的分子设计

Damla Sürmeli1, Tristan C Dinsmore1, Haley M Anchukaitis1

  • 1Department of Chemistry, Tufts University, Medford, MA, United States.

Methods in enzymology
|June 17, 2024
PubMed
概括

研究人员通过修改其结构以抵抗酶降解来提高糖尿病和肥胖治疗的激素稳定性. 这种方法保持了治疗疗效,同时改善了药物的寿命,而不改变核心序列.

关键词:
化学组件组件是一个化学组件.在N-终端修改.类治疗药物 类治疗药物药理学 药理学是指药理学的学科.蛋白质酶耐药性 蛋白质酶耐药性

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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
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