氧化应激对糖尿病患者心肌功能的影响:侧重于亚临床左心室功能障碍
1Cardiology Department, Altinbas Universitesi, Istanbul, Turkey dogacoksen@gmail.com.
BMJ open diabetes research & care
|June 17, 2024
概括
氧化应激会对左心室功能产生负面影响,特别是在糖尿病中. 这项研究发现,与健康个体相比,增加的氧化应激显著恶化了DM患者的心肌功能.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 生物化学 生物化学
背景情况:
- 氧化应激与左心室功能不良有关.
- 糖尿病 (DM) 和氧化应激有着强烈的双向关系.
- 左心室功能障碍在DM患者中很普遍,即使没有其他危险因素.
研究的目的:
- 为了比较研究氧化应激和亚临床左心室功能障碍 (SCLVD) 之间的关系.
- 通过心肌性能指数 (MPI) 评估SCLVD.
- 在患有和没有DM的患者中评估这些参数.
主要方法:
- 一项观察性,横截面,单中心研究,涉及151名患者.
- 氧化应激标志物的评估:总氧化剂状态 (TOS),总抗氧化剂状态 (TAS) 和氧化应激指数 (OSI).
- 评估SCLVD使用组织多普勒回声心脏学来计算MPI.
主要成果:
- 与健康组 (70名患者) 相比,DM组 (81名患者) 的平均TOS和OSI值显著更高.
- 糖尿病组的TAS平均值明显低于健康组.
- 在DM组中观察到OSI和MPI之间的显著正相关性 (R=0.554,p<0.001),但在健康组中没有.
结论:
- 氧化应激和心肌功能障碍在患有DM的患者中更为普遍.
- 研究结果支持氧化应激对心肌功能有负面影响.
- 与健康个体相比,高氧化应激导致DM患者的MPI恶化更大.
相关概念视频
Pathophysiology of Cardiac Performance
632
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
632
Ischemic Heart Disease: Overview
1.3K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.3K


