严重的精神疾病与痴呆症的风险增加有关
Joshua Stevenson-Hoare1, Sophie E Legge1, Emily Simmonds2
1Cardiff University, Cardiff, UK.
BMJ mental health
|June 17, 2024
概括
精神疾病如精神分裂症,双相情感障碍和抑郁症显著增加痴呆风险. 早期发现和管理心理健康状况对于预防痴呆症至关重要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 患有精神疾病的人面临患痴呆症的风险更高.
- 有限的纵向数据存在于焦虑,双相和精神病障碍在痴呆中的作用.
- 电子健康记录 (EHR) 为精神疾病和痴呆症研究提供大规模的寿命数据.
研究的目的:
- 调查精神分裂症,双相情感障碍/躁狂症,抑郁症和焦虑症与随后痴呆风险之间的关联.
- 使用两个大型基于人口的样本与EHR数据.
主要方法:
- 分析了威尔士近100万名成年人的EHR数据.
- 包括228,937名英国生物银行参与者.
- 检查特定精神疾病和随后的痴呆症诊断之间的关系.
主要成果:
- 在诊断痴呆症之前,精神疾病发病率显著增加,在前一年达到顶峰.
- 精神分裂症,双相情感障碍/躁狂症和抑郁症与痴呆风险增加显著相关 (HRs从1.63到4.46).
- 焦虑也与更高的痴呆风险有关 (HR=1.34),在精神疾病发作时,在所有年龄组观察到的风险增加.
结论:
- 精神疾病与发展痴呆症的风险增加有关.
- 痴呆的风险随着精神疾病的严重程度而增加.
- 晚期发病的精神障碍可能表明初始痴呆症,需要临床关注.
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