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Updated: Jun 23, 2025

Handling of the Cotton Rat in Studies for the Pre-clinical Evaluation of Oncolytic Viruses
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非复制性和型复制性选择性HSV载体的安全性

Alberto L Epstein1, Samuel D Rabkin2

  • 1EG 427 SAS, 29 Rue du Faubourg Saint Jacques, 75014 Paris, France.

Trends in molecular medicine
|June 17, 2024
PubMed
概括

简单疹病毒1型 (HSV-1) 载体对基因和癌症治疗具有前景. 这些载体耐受性很好,可以重复使用,并显示出临床应用的潜力.

关键词:
癌症治疗疗法 癌症治疗临床试验中的临床试验.基因治疗的基因疗法疹简单病毒病毒.科性病毒病毒.

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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