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全球30天内为穿孔性胃潰瘍手术的发病率和死亡率:GRACE研究
Mohamed Abouelazayem1,2,3, Rajesh Jain4, Michael S J Wilson5
1Department of Surgery, University College London Hospitals, London, UK. m.abouelazayem@nhs.net.
Surgical endoscopy
|June 17, 2024
概括
穿孔性胃潰瘍 (PPU) 的手術具有高的全球30天病發率和死亡率. 高龄,女性性别和呈现时的震惊是关键的危险因素. 这凸显了及时干预和风险分层的必要性.
科学领域:
- 全球手术全球手术
- 胃肠病学 胃肠病学
- 外科手术的结果
背景情况:
- 有限的国际数据存在与穿孔性胃潰瘍 (PPU) 手术相关的发病率和死亡率.
- 了解全球结果对于改善患者护理和外科手术策略至关重要.
研究的目的:
- 确定为PPU进行手术的患者的全球30天发病率和死亡率.
- 为了确定与PPU手术后增加的发病率和死亡率相关的患者和临床因素.
主要方法:
- 进行了一项国际队列研究,涉及2022年1月1日至6月30日期间接受PPU手术的成年患者.
- 患者按年龄 (>50岁) 和症状发作到入院时间 (>24小时) 分层.
- 使用单变量和多变量分析来确定与30天发病率和死亡率相关的因素.
主要成果:
- 该研究包括来自52个国家的159个中心的1874名患者,30天发病率为48.5%,死亡率为9.3%.
- 与30天发病率和死亡率增加相关的因素包括年龄较大 (>50岁),女性性别,入院时的冲击和急性损伤.
- 延迟呈现 (>24小时) 与较高的发病率有关,但与死亡率无关.
结论:
- 穿孔性胃潰瘍 (PPU) 的手術與全球顯著的30天病發率和死亡率有關.
- 年龄较大,女性性别,以及与震惊的呈现是预测不良结果的关键因素.
- 这些发现强调了在PPU患者中迅速进行手术干预和风险因素管理的重要性.
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