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The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
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通过猪肠微生物群的知识图衍生的料效率分析.

Junmei Zhang1, Qin Jiang1,2, Zhihong Du1

  • 1National Key Laboratory of Agricultural Microbiology, College of Informatics, College of Animal Sciences and Technology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.

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概括

这项研究引入了猪肠微生物知识图 (PGMKG),以将猪肠微生物与料效率 (FE) 联系起来. PGMKG集成数据以识别影响FE的关键微生物和途径,以进行有针对性的优化.

关键词:
料效率 料效率是指料的使用效率.我们的肠道微生物群.知识图表知识图表猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪

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科学领域:

  • 动物科学动物科学
  • 微生物学 微生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 猪的料效率 (FE) 对生产至关重要,肠道微生物群发挥着重要作用.
  • 关于肠道微生物群和FE的现有研究是分散的,缺乏综合的生物背景.
  • 目前用于微生物群分析的结构化数据库往往错过了全面的生物过程信息.

研究的目的:

  • 开发一个全面的知识图 (PGMKG),整合关于猪肠道微生物和FE的文字和结构化数据.
  • 调查猪肠道微生物群与料效率之间的复杂关系.
  • 确定影响FE的关键微生物,代谢物和途径,以进行有针对性的优化.

主要方法:

  • 从157个出版物中构建了pgmReading知识库和域本体学.
  • 扩展的语义信息使用PubTator创建pgmPubtator.
  • 整合了ADDAGMA,gutMGene和KEGG数据库,形成了pgm数据库.
  • 将这些资源结合到猪肠微生物知识图 (PGMKG) 中.
  • 使用五个生物查询案例验证了PGMKG性能.

主要成果:

  • 成功创建了猪肠微生物知识图 (PGMKG).
  • 鉴定出影响猪料效率的微生物.
  • 提供了对影响FE的微生物代谢物和相关代谢途径的洞察.
  • 证明了PGMKG能够绘制关键微生物的地图,并指导微生物群向优化.

结论:

  • PGMKG提供了一种全新的,综合的方法来了解猪肠道微生物群和FE.
  • 知识图有助于识别改善FE的微生物标.
  • 这项研究为猪生产中针对微生物群的策略提供了基础.