有机化肥在全球土壤微生物群中共同选择了与基因相关的抗生素和金属耐药性基因
Zi-Teng Liu1, Rui-Ao Ma1, Dong Zhu2
1Shanghai Key Lab for Urban Ecological Processes and Eco-Restoration, School of Ecological and Environmental Sciences, East China Normal University, Shanghai, China.
Nature communications
|June 17, 2024
概括
有机肥料增加了抗生素和金属耐药性基因 (ARG/MRG) 在土壤中的共同选择. 这项研究揭示了遗传联系,并突出了传播风险高的地区,强调了公共卫生问题.
科学领域:
- 环境微生物学 环境微生物学
- 基因组学就是基因组学.
- 公共卫生 公共卫生
背景情况:
- 抗生素耐药性基因 (ARG) 和金属化物耐药性基因 (MRG) 经常在农业土壤中一起发现.
- 在有机肥过程中,ARG和MRG的遗传联系和共同选择机制尚未完全理解.
研究的目的:
- 在受有机肥料影响的农业土壤中研究ARG和MRG的遗传联系和共同选择.
- 评估与共抗性基因相关的全球分布和潜在风险.
主要方法:
- 分析了511个全球农业土壤元基因组.
- 基因转录分析用于评估在压力下基因表达.
- 构建与毒性和移动基因共存的ARG-MRGs的全球地图.
主要成果:
- 与非有机土壤相比,有机肥料显著增加了携带ARG-MRG的结合物 (AMCC) 的多样性和丰度,增加了三倍.
- 转录组数据显示ARG-MRG对的共同调节,特别是在压力下.
- 全球地图显示,ARG-MRG在北美中部,东欧,西亚和中国东北地区的传播风险 (4-6) 较高.
结论:
- 有机化肥促进了全球土壤微生物群中ARG和MRG的基因共同选择.
- 同耐药基因的传播带来潜在的致病性风险,需要采取缓解策略.
- 了解这些共同选择动态对于保护公共健康至关重要.
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