甲状腺功能障碍症增加了60-80岁的个体骨关节炎的风险
Jinlong Zhao1,2,3, Haodong Liang1,4,5, Guihong Liang1,2,3
1State Key Laboratory of Traditional Chinese Medicine Syndrome/The Second Clinical College of Guangzhou University of Chinese Medicine, No.111, Dade Road, Yuexiu District, Guangzhou, 510405, Guangdong, China.
Scientific reports
|June 17, 2024
概括
甲状腺功能障碍症显著增加了骨关节炎的风险,特别是在老年人中. 这项研究证实了因果关系,强调了进一步研究潜在机制的必要性.
科学领域:
- 内分泌学 在内分泌学.
- 类风湿病学 类风湿病学
- 遗传学 遗传学 是一个
背景情况:
- 甲状腺功能增强症和骨关节炎 (OA) 之间的关系在很大程度上是未知的.
- 甲状腺功能障碍是一种由过度活跃的甲状腺特征的疾病.
研究的目的:
- 为了调查甲状腺功能障碍和骨关节炎之间的关联和因果关系.
- 为了确定甲状腺功能障碍是否是发展OA的危险因素.
主要方法:
- 利用了国家健康和营养检查调查 (2007-2012) 的7433名参与者的数据.
- 采用加权多变量调整后勤回归和三个门德尔随机化 (MR) 方法来评估甲状腺功能障碍和OA的关系.
- 进行了敏感性分析,包括异质性,性和留出一个测试.
主要成果:
- 甲状腺功能障碍与关节炎的风险增加显著相关 (OR=2.23,P=0.018).
- 在60至80岁的年龄组中,这种关联更为强烈 (OR=2.86,P=0.002).
- 核磁共振分析证实甲状腺功能增高和骨关节炎风险增加之间存在因果关系 (IVW OR=1.23,P=0.017).
- 反向MR分析表明,OA不会增加甲状腺功能障碍的风险 (OR=1.02,P=0.449).
结论:
- 甲状腺功能障碍是发展骨关节炎的重要危险因素.
- 这种因果关系得到了观察和遗传分析的支持.
- 需要进一步的研究来阐明连接甲状腺功能增高和OA的病理机制.
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