高脉冲波速度与痴呆症的周围血管空间扩大有关,其中包括勒维体
Naoki Saji1, Yoshino Kinjo2,3, Kenta Murotani4
1Center for Comprehensive Care and Research On Memory Disorders, Hospital, National Center for Geriatrics and Gerontology, 7-430 Morioka, Obu, Aichi, 474-8511, Japan. sajink@nifty.com.
Scientific reports
|June 17, 2024
概括
基底中的扩大周周血管空间 (EPVS) 与患有莱维体痴呆症 (DLB) 有关. 高脉冲波速度 (PWV) 可能会加速DLB患者的EPVS发展.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 血管生物学 血管生物学
背景情况:
- 扩大的周血管空间 (EPVS) 与阿尔茨海默病有关.
- 在EPVS和痴呆症与勒维体 (DLB) 之间的关系仍然不清楚.
研究的目的:
- 调查EPVS和DLB之间的关联.
- 探索脉冲波速度 (PWV) 在EPVS和DLB中的作用.
主要方法:
- 预期队列的横截面分析 (109名参与者,16名患有DLB).
- 评估认知功能,PWV和大脑MRI特征.
- 多变量逻辑回归用于评估EPVS和DLB之间的关系.
主要成果:
- 与对照组相比,DLB组显示基底腺EPVS的可能性更高.
- EPVS存在与年龄较大,认知障碍和高PWV相关.
- 基底质EPVS与DLB独立相关;高PWV与基底质和半圆中心的EPVS有关.
结论:
- 基底质EPVS与DLB独立相关.
- 高PWV可能通过脑血管脉动性导致DLB中加速的EPVS.
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