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Updated: Jun 23, 2025

Quantifying Replication Stress in Ovarian Cancer Cells Using Single-Stranded DNA Immunofluorescence
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Quantifying Replication Stress in Ovarian Cancer Cells Using Single-Stranded DNA Immunofluorescence

Published on: February 10, 2023

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在APOBEC3A介导的复制应激过程中,SMC5/6复合物防止了基因毒性

Dylan F Fingerman1,2, David R O'Leary1,2, Ava R Hansen1,2,3

  • 1Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.

The EMBO journal
|June 17, 2024
PubMed
概括

染色体5/6 (SMC5/6) 结构维护复合体对于当APOBEC3A导致DNA损伤时细胞生存至关重要. SMC5/6 功能障碍阻止了 APOBEC3A 突变发生,揭示了潜在的癌症治疗标.

关键词:
癌症变异发生的原因是癌症的变异.赛蒂丁脱胺酶的使用基因组的完整性突变的签名 突变的签名复制 压力 复制 压力

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Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks12:19

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