周围血液单核细胞呼吸功能与渐进的玻璃眼性视力丧失有关
Bledi Petriti1,2, Alessandro Rabiolo3, Kai-Yin Chau2
1NIHR Biomedical Research Centre, Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.
Nature medicine
|June 17, 2024
概括
较低的外周血液单核细胞氧消耗率 (OCR) 和尼古丁胺氨酸二核酸 (NAD) 水平是渐进性玻璃眼瘤的新生物标志物,即使有降低眼内压力的治疗.
科学领域:
- 眼科医生 眼科 眼科
- 细胞的新陈代谢
- 生物标志物发现发现
背景情况:
- 眼内压力 (IOP) 是青光眼的主要可改变的风险因素,目前的治疗方法旨在降低它.
- 尽管有降内血压的疗法,但许多青光眼患者的视力持续下降,这凸显了需要新的预后标志物.
- 识别渐进性视力丧失的生物标志物对于有效的绿眼病管理至关重要.
研究的目的:
- 调查外围血液单核细胞 (PBMC) 氧气消耗率 (OCR) 和尼古丁胺胺氨基二核酸 (NAD) 水平作为青光眼进展的潜在生物标志物.
- 评估PBMC OCR和视野 (VF) 进展在接受IOP降低治疗的青光眼患者之间的关联.
- 为了比较PBMC的OCR和NAD水平在青光眼患者和健康对照者之间.
主要方法:
- 在使用呼吸计测定方法测量青光眼患者和对照组中测量的PBMC OCR.
- 在玻璃眼患者和对照组中评估PBMC NAD水平.
- 相关的PBMC OCR与视野进展的速度在治疗青光眼的患者.
- 分析了基线IOP和PBMC OCR在青光眼患者之间的关联.
主要成果:
- 较低的PBMC OCR显着与接受IOP降低治疗的青光眼患者的VF进展更快相关,解释了13%的差异.
- 与健康对照人群相比,PBMC OCR在青光眼患者中明显较低.
- 青光眼患者的PBMC NAD水平低于对照患者,并且与OCR有很强的相关性.
- 在未接受治疗的患者中,IOP解释了16%的VF进展,而PBMC OCR则在接受治疗的患者中成为显著的预测因素.
结论:
- PBMC OCR 和 NAD 水平显示为预测青光眼进展的新生物标志物具有前途.
- 这些细胞代谢标志物可能会提供超越IOP的疾病机制的见解.
- 对PBMC OCR和NAD的进一步研究可能会导致改善对玻璃眼的监测和个性化治疗策略.
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