调节与先天免疫相关的基因,从而产生预防性的抗微生物和抗病毒特性
Veronica Ferrucci1,2,3, Marco Miceli4, Chiara Pagliuca5
1Department of Molecular Medicine and Medical Biotechnology (DMMBM), University of Naples 'Federico II', Via Sergio Pansini 5, 80131, Naples, Italy. veronica.ferrucci@unina.it.
Journal of translational medicine
|June 17, 2024
概括
这项研究表明,一种含有多和多酸盐的新型营养配方有效地对抗SARS-CoV-2,流感和RSV. 该配方还显示了对常见的共感染细菌和真菌的抗微生物特性,支持先天免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在共同感染期间,先天性免疫力衰竭可能导致免疫调节失调.
- 呼吸系统病毒,如SARS-CoV-2,流感 (FLU-A-B-C) 和呼吸系统同胞病毒 (RSV) 是常见的共感染,特别影响弱势群体.
- 细菌和真菌病原体 (例如,金黄色葡萄球菌,白菌) 经常同时感染COVID-19的患者,增加了发病率.
研究的目的:
- 评估一种新型营养药配方 (Solution-3) 的抗病毒,抗菌和抗真菌性能.
- 研究营养药配方在增强先天免疫反应中的免疫调节机制.
- 评估营养药配方中的多和多酸盐对呼吸道病原体和并发感染的协同作用.
主要方法:
- 使用UHPLC-Q-Orbitrap HRMS来量化Solution-3中的多.
- 在BLS3实验室使用qPCR对SARS-CoV-2 (EG.5),FLU-A和RSV-A进行了抗病毒活性测试.
- 细菌和真菌的最小抑制和杀菌度 (MIC/MBC) 被确定;转录组分析 (RNAseq) 和ELISA被用于研究作用机制.
主要成果:
- 这种营养药物配方结合了多 (,Verbascum thapsus L.,Thymus vulgaris L.) 和多酸盐 (polyPs),显示出协同的抗病毒,抗菌和抗真菌活性.
- 该配方通过增强细胞因子 (IFNγ,TNFα,IL-10,IL-6/12),化学因子 (CXCL1),抗菌 (HBD-2,LL-37) 和补充系统组件 (C3) 来增强先天免疫反应.
- 观察到对SARS-CoV-2,FLU-A,RSV-A,格拉姆阳性/阴性细菌和Candida albicans的有效活性.
结论:
- 营养药配方对关键的呼吸道病毒和常见的共同感染口腔微生物表现出预防性抗菌成功.
- 这种配方预计将在管理与病毒性呼吸道疾病相关的并发感染方面具有价值.
- 这些发现支持这种营养药方法在增强对各种病原体的天生的免疫力方面的潜力.
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