结核病相关贫血严重程度与儿童结核病引起的炎症的相关性:一项为期六年的回顾性研究
Chunjiao Han1,2, Yulian Fang1, Lili Dong3
1Tianjin Children's Hospital, Children's Hospital of Tianjin University, Tianjin Pediatric Research Institute, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, Tianjin, China.
贫血影响了超过三分之一的肺结核 (TB) 儿童. 这种情况,通常是轻微的微细胞性缺血性贫血,与炎症严重程度相关,并随着治疗而改善.
科学领域:
- 儿童传染病 儿童传染病
- 血液学 血液学 血液学
- 结核病的研究研究.
背景情况:
- 贫血是结核病 (TB) 患者经常出现的并发症.
- 缺乏对儿科结核病贫血的系统研究.
- 这项研究调查了结核病儿童的贫血细节.
研究的目的:
- 描述结核病儿童的贫血特征.
- 将贫血与临床特征和炎症联系起来.
- 评估贫血作为儿童结核病严重性生物标志物.
主要方法:
- 对103名肺结核 (PTB) 儿童进行了回顾性分析.
- 根据血红蛋白 (Hb) 水平分类为贫血和非贫血组.
- 逻辑回归和斯皮尔曼相关性分析用于关联.
主要成果:
- 在儿童结核病患者中,贫血患病率为37.9%.
- 与较低的白蛋白和较高的白血球,CRP,LDH,ESR相关的贫血.
- Hb和炎症标志物之间存在显著的负相关性.
- 76.9%的儿童在一个月的抗结核疗法 (ATT) 后恢复正常Hb.
结论:
- 贫血是常见的儿童结核病在诊断时.
- 轻度至中度的微细胞性缺血性贫血占主导地位.
- 贫血的严重程度与结核病引起的炎症有很强的相关性.
- 贫血是儿童结核病严重程度的生物标志物.
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