早期初潮与乳腺瘤分子特征和复发的关联
Alexandra R Harris1,2,3, Tengteng Wang4, Yujing J Heng5,6
1Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA. alexandra.harris2@nih.gov.
Breast cancer research : BCR
|June 17, 2024
概括
早期初潮,即12岁之前的月经开始,与更具侵略性的乳腺癌分子特征有关. 这一发现表明了乳腺癌预防和治疗的潜在新策略.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 分子生物学分子生物学
背景情况:
- 早期初潮 (12岁之前) 是已知的乳腺癌风险因素.
- 关联早期初潮与乳腺癌瘤生物学和预后的分子机制尚不清楚.
研究的目的:
- 研究初潮早期与乳腺瘤的分子/预后特征之间的关联.
- 为了确定与乳腺癌早期初潮相关的基因表达模式.
主要方法:
- 从护士健康研究 (NHS) 中,在846个乳腺瘤和666个相邻的正常组织中进行了全转录组基因表达概况.
- 多变量回归,基因组丰富分析和TCGA中的外部验证.
- 使用LASSO回归的PAM50亚型和早期初潮基因表达特征的发展.
主要成果:
- 早期初潮与参与细胞外基因,细胞粘附和侵入正常组织的基因有关.
- 在瘤和正常组织中,癌症标志性通路 (扩散,氧化应激,炎症) 的升级.
- 与更高的PAM50扩散和复发风险得分以及具有攻击性分子亚型 (基底类,HER2丰富) 的关联.
结论:
- 早期初潮与更具侵略性的乳腺瘤分子特征有关.
- 早期初潮的基因表达特征预测了更糟糕的10年无疾病生存率.
- 了解这种关系可能会为乳腺癌的新型二次预防策略提供信息.
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