精神病学研究中的知识图:潜在的应用和未来的前景
Sebastian Freidel1,2, Emanuel Schwarz1,2
1Hector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Acta psychiatrica Scandinavica
|June 17, 2024
概括
知识图 (KG) 为精神病学研究提供了巨大的潜力,利用AI和LLMs. 本综述强调了KG的应用,以促进心理健康障碍的理解和治疗.
科学领域:
- 综合计算精神病学综合计算精神病学
- 生物医学信息学是生物医学信息学.
- 医疗保健中的人工智能
背景情况:
- 尽管知识图在更广泛的生物医学领域发挥着既定的作用,但知识图在精神病学研究中尚未得到充分利用.
- 基因组作为有价值的知识数据库,并促进生物医学实体之间的新型关系的检测.
- 人工智能 (AI) 和大型语言模型 (LLM) 的整合为精神病学中的KG应用提供了新的机会.
研究的目的:
- 探索和概述知识图 (KG) 的潜力,以推进精神病学研究.
- 在精神病学领域确定和推KG应用的特定用例.
- 弥合KG在相关领域的现有应用程序与其在心理健康研究中的潜力之间的差距.
主要方法:
- 在计算机科学,知识工程和生物信息学方面进行了全面的文献审查.
- 使用相关关键字搜索主要的学术数据库 (PubMed,语义学者,谷歌学者).
- 评估和综合出版物,以适用于未来的精神病学研究.
主要成果:
- 在相关的研究领域中发现了众多KG应用,这些应用目前在精神病学中未得到充分利用.
- 详细建议计算研究人员利用现有的KG应用程序进行精神病学研究.
- 强调了KG在生物标志物发现和个性化医学等领域的潜力.
结论:
- 知识图为阐明精神疾病复杂生物学提供了一个有希望的途径.
- 基于KG的研究可以促进精神病学的创新干预和个性化医疗方法的发展.
- 在精神病学研究中利用基因基因存在重大机遇,包括患者分层和生物标志物发现.
相关概念视频
Human Genetics
557
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
557
Issues And Trends In Healthcare Delivery System
5.6K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.6K
Theoretical Approaches to Psychological Disorder
217
The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
217
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
569
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
569
Psychosis: Goals of Pharmacotherapy
122
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
122
Diagnostic and Statistical Manual of Mental Disorders (DSM)
54
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
54


