在高血压小鼠中,中风后的认知障碍和脑出血增加了
David E Wong Zhang1,2, Tayla A Gibson Hughes1,2, Hericka B Figueiredo Galvao1,2
1Centre for Cardiovascular Biology and Disease Research and La Trobe Institute for Molecular Sciences (LIMS), La Trobe University, Victoria, Australia.
概括
高血压与中风相结合显著恶化了小鼠的认知障碍和脑损伤. 这项研究强调了并发性高血压和中风对神经结果的有害影响.
科学领域:
- 神经科学是一个神经科学.
- 心血管研究研究心血管研究
- 基因组学就是基因组学.
背景情况:
- 高血压是已知的中风和认知衰退的危险因素.
- 高血压对中风后认知障碍的具体影响尚不清楚.
研究的目的:
- 研究高血压和中风对脑损伤,认知功能和大脑转录形状的综合影响.
- 阐明与中风相关的认知缺陷的高血压引起的恶化背后的分子机制.
主要方法:
- 使用一种小鼠模型 (C57BL/6J) 诱导高血压 (血管激素II输注) 和光血栓性中风,准前额叶皮层.
- 使用巴恩斯迷宫测试评估认知功能.
- 通过RNA测序分析了大脑的转录变化.
主要成果:
- 遭受中风的高血压小鼠在巴恩斯迷宫中显著增加了逃脱延迟,表明学习和记忆受损.
- ангиотензин II 治疗导致中风后自发出血.
- RNA测序确定了1500多个与神经炎症,亡,microRNAs,自和Wnt信号相关的差异表达基因,在高血压中风组与正常压力中风组相比.
结论:
- 高血压和中风的结合导致比单独的中风更严重的学习障碍和脑损伤.
- 高血压通过涉及神经炎症和改变分子通路的机制加剧中风引起的认知缺陷.
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