在患有手术后低甲状腺功能障碍的患者中,生活质量受损
Danisa Ivanovic-Zuvic1, Slavka Chelebifski2, Benjamin Uribe2
1Department of Endocrinology, Hospital del Salvador, Santiago, Chile.
Journal of bone metabolism
|June 18, 2024
概括
手术后的小甲状腺功能障碍严重损害了生活质量,并增加了疲劳和记忆问题等症状. 这凸显了在差异化甲状腺癌患者中需要仔细进行手术规划的必要性.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 手术 手术 手术 术 术
背景情况:
- 副甲状腺功能障碍症会导致慢性低血症,原因是副甲状腺激素水平较低.
- 甲状腺手术是造成阳性甲状腺功能低下症的主要原因.
- 有限的数据存在于hypoparathyroidism对拉丁美洲生活质量的影响.
研究的目的:
- 描述术后偏偏甲状腺症患者的临床表现和生活质量.
- 为了比较经过分化甲状腺癌全甲状腺切除术后患有和没有术后偏偏甲状腺症的患者之间的结果.
主要方法:
- 病例控制研究涉及106名因分化甲状腺癌接受全甲状腺切除术的患者 (>18岁).
- 第1组 (病例):术后偏偏甲状腺症 (N=41). 第2组 (对照组):没有术后偏偏甲状腺症 (N=65).
- 通过临床记录,SF-36v2生活质量调查和结构化症状调查收集的数据;进行了物流多变量回归分析.
主要成果:
- 术后偏偏甲状腺症患者年轻,有更多的淋巴结切除,并接受了更多的I-131治疗.
- 第1组报告了明显较低的身体功能得分 (OR 3.8) 和整体精神/身体组件得分.
- 常见的症状包括麻醉,疲劳和记忆力变化;治疗坚持率为56% () 和71% (醇);24%的患者经历了不良药物效应.
结论:
- 术后偏偏甲状腺症与生活质量受损和频繁的症状有关.
- 治疗坚持程度有限和药物不良影响是令人担忧的重要因素.
- 这些发现需要考虑差异化甲状腺癌的外科替代方案,以最大限度地降低甲状腺功能低下的风险.
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