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Updated: Jun 13, 2026

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
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通过计数尖峰来光学检测传染性SARS-CoV-2病毒

Denis S Kudryavtsev1,2, Vera A Mozhaeva1, Igor A Ivanov1

  • 1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the RAS, Moscow 117997, Russia.

Nanoscale
|June 18, 2024
PubMed
概括

这项研究引入了一种用于快速检测SARS-CoV-2的新型光学显微镜方法. 该技术通过计算表面尖峰来区分传染性和非传染性病毒颗粒,克服了当前病毒检测方法的局限性.

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Coronavirus

Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...