相关实验视频

Updated: Jun 21, 2026

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

Published on: June 7, 2018

重新定义与人环素相关的亚临床心脏毒性:"绝对"和"相对"变化纵向应变

Andrew Terluk¹, Luke Stefani^2,3, Anita Boyd⁴

¹Westmead Clinical School, The University of Sydney, Camperdown, Australia.

ESC heart failure

|June 18, 2024

概括

在乳腺癌患者中,抗环素化疗可能会导致心脏功能障碍. 全球纵向菌株 (GLS) 有助于早期发现心脏问题,指导心脏保护策略,并识别患有较低风险的患者,尽管发生过渡性变化.

科学领域:

心脏病学心脏病学
在瘤学瘤学.
医疗成像医学成像

背景情况:

乳腺癌的抗环素化疗 (AC) 可能导致与癌症治疗相关的心脏功能障碍 (CTRCD).
传统上,CTRCD被定义为左心室 (LV) 喷射分数 (LVEF) 在心声回声学上减少.
全球纵向应变 (GLS) 越来越多地用于在明显的CTRCD发生之前检测亚临床心脏功能障碍.

研究的目的:

在接受AC的乳腺癌患者中评估亚临床心脏功能障碍.
确定与GLS显著变化相关的回声心脏学和患者因素.
通过GLS完善CTRCD的定义和评估.

主要方法:

有望招募114名接受AC治疗的HER2阴性乳腺癌患者.
序列心声图 (LVEF和LVGLS) 在基线,3个月和1年进行.
通过LVEF减少和亚临床LV功能障碍通过GLS相对减少≥10%来定义CTRCD.

主要成果:

没有参与者符合CTRCD的LVEF标准.
38%的患者 (43/114) 在12个月后显示GLS的相对减少≥10%.
与降低绝对GLS (<16%) 相关的因素包括年龄,高血压,增加LV质量,以及较低的基线e'速度和GLS.

结论:

使用相对和绝对GLS变化的逐步评估可以识别亚临床LV功能障碍.
患有高基线GLS的患者可能会被重新分层到较低风险的群体中,即使GLS有暂时的下降.
在AC期间,GLS是监测心脏功能的宝贵工具,并为心脏保护策略提供信息.

关键词:

抗环素化学疗法抗环素化学疗法乳腺癌乳腺癌乳腺癌全球纵向性心应变菌株跨胸腔心脏回声学 (Transthoracic echocardiography) 是一种心脏回声学.

更多相关视频

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation

Published on: October 20, 2022

相关概念视频

Myocarditis I: Introduction

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...

Cardiomyopathy IV: Restrictive Cardiomyopathy

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...