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改变了岛内质瘤患者的大脑网络

Qifeng He¹, Zuocheng Yang¹, BoWen Xue¹

¹Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

CNS neuroscience & therapeutics

|June 18, 2024

概括

岛屿质瘤相关 (GRE) 显著改变大脑网络,特别是视觉,感官运动和默认模式网络. 这些变化影响网络特性,取决于质瘤的半球位置.

科学领域:

神经科学是一个神经科学.
神经成像是一种神经成像.
发病学 (Epileptology) 是一个专业的学科.

背景情况:

岛屿质瘤可能导致,影响大脑功能.
了解大脑网络的改变对于管理质瘤相关 (GRE) 至关重要.

研究的目的:

通过静止状态功能磁共振成像 (fMRI) 来研究与岛内质瘤相关的 (GRE) 患者的大脑网络变化.
为了比较GRE,没有的质瘤 (GnE) 和健康的对照 (HC) 组之间的网络特性.

主要方法:

收集了62名岛屿质瘤患者 (分为GRE和GNE) 和16名健康对照者的fMRI数据.
应用图形理论分析来评估传感运动,默认模式,视觉和执行网络.
基于质瘤半球位置的网络变化进行比较.

主要成果:

在岛屿结质瘤的两个半球中都没有发现显著的功能连接性改变.
图形理论揭示了群体之间的视觉,感觉运动和默认模式网络 (p <0.05) 的显著差异.
与GNE患者相比,GRE患者的中心度降低 (左半球) 和节点效率/聚类降低 (右半球).

结论:

岛屿质瘤和GRE对大脑网络有广泛的影响.
半球位置影响由岛屿GRE改变的特定大脑网络.
与单独的岛屿质瘤相比,GRE与大脑网络中的节点特性减少有关.

关键词:

大脑网络大脑网络是一种.质瘤质瘤是一种胰岛素质瘤胰岛素质瘤

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