横向的双臂核天体细胞控制食物摄入量
Devesh Mishra1, Jennifer E Richard1,2, Ivana Maric1,3
1Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
侧侧核 (lPBN) 中的星细胞控制着养行为. 激活这些星球细胞会导致厌食症,由谷氨酸信号和外周激素调节,在饮食引起的肥胖症中具有性别特异性影响.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 内分泌学 在内分泌学.
背景情况:
- 食物摄入量受到中央监管,传统上研究神经元.
- 星球细胞曾经被忽视,现在被认为是它们在养控制中的作用.
- 研究主要集中在下丘脑和背部阴道复合体天体细胞上,并没有研究侧侧核 (lPBN).
研究的目的:
- 为了研究星体细胞在侧侧核 (lPBN) 在控制养行为中的作用.
- 确定lPBN中的星细胞激活是否影响雄性和雌性大鼠的食物摄入.
- 探索由天体细胞介导的养控制背后的机制,包括谷氨酸信号和外围养信号的调制.
主要方法:
- 雄性和雌性大鼠的侧侧核 (lPBN) 中天体细胞的化学遗传激活.
- 在随意和禁食条件下评估养行为.
- 对N-甲基D-酸盐 (NMDA) 受体的药理学阻断.
- 用葡萄糖类-1和格林的管理.
- 诱导饮食引起的肥胖.
主要成果:
- 激活lPBN天体细胞诱导了两性显著的厌食症.
- 谷氨酸信号传递,特别是通过NMDA受体,与星球细胞诱导的厌食症有关.
- lPBN天体细胞激活调节了葡萄糖类-1和格林的养效应.
- 饮食诱导的肥胖影响了LPBN天体细胞诱导的厌食症以性别不同的方式.
结论:
- 侧侧核 (lPBN) 中的星体细胞在调节养行为中起着至关重要的作用.
- 谷氨酸信号传递和外围肠-大脑激素是lPBN中星球细胞功能的关键媒介.
- 这些发现揭示了在食控制中的一种新型星细胞机制,对肥胖和代谢障碍有影响.
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