甲状腺功能低下症和代谢性心血管疾病
Armando Patrizio1, Silvia Martina Ferrari2, Giusy Elia3
1Department of Emergency Medicine, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Frontiers in endocrinology
|June 18, 2024
概括
像甲状腺功能低下症这样的甲状腺疾病会影响心血管疾病 (CVD) 的风险. 用levothyroxine治疗亚临床甲状腺功能低下症显示有好处,特别是在年轻人中,但对于老年人来说仍有争议.
科学领域:
- 内分泌学和心血管医学.
- 甲状腺激素在心血管生理学中的作用
- 甲状腺功能障碍和心血管疾病的流行病学.
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因.
- 甲状腺功能障碍,包括甲状腺功能过高和甲状腺功能低下,在成年人中很普遍.
- 这两种甲状腺疾病都会影响心血管疾病的发展和进展.
研究的目的:
- 审查甲状腺激素在心血管健康中的作用.
- 分析明显甲状腺功能低下症 (OH) 和亚临床甲状腺功能低下症 (SCH) 对心血管风险和死亡率的临床影响.
- 总结有关levothyroxine (L-T4) 对SCH治疗的证据.
主要方法:
- 对关联甲状腺激素与心血管功能的生理机制的审查.
- 对明显和亚临床甲状腺功能低下症的最新临床数据的分析.
- 目前证据和关于治疗亚临床甲状腺功能低下症的指导方针的总结.
主要成果:
- 甲状腺激素的变化会影响心脏功能,血压,内皮功能和脂质概况.
- 目前的指导方针建议用TSH> 10mIU/L治疗SCH,在年轻人群中更明显的好处.
- 在65岁以上的个人中,Levothyroxine治疗SCH仍然存在争议.
结论:
- 甲状腺功能障碍显著影响心血管健康和死亡率.
- 对SCH的Levothyroxine治疗已经证明有好处,特别是在年轻人身上.
- 进一步的研究至关重要,以指导SCH老年患者心血管风险的临床管理.
相关概念视频
Psychoneuroimmunology: Cardiovascular Disease
30
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
30
Overview of Carbohydrate Metabolism
902
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
902
Functions of Thyroid Hormones
2.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.7K
Cardiovascular Drugs: Classification based on Therapeutic Indications
2.3K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
2.3K
Exercise and Cardiovascular Response
780
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
780
Cholesterol: Significance and Regulation
535
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
535


