使用文档术语矩阵和XGBoost的药物诱导肝损伤的自动文本分类
Minjun Chen1, Yue Wu1, Byron Wingerd2
1Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, United States.
Frontiers in artificial intelligence
|June 18, 2024
概括
这项研究使用人工智能从药物标签上对药物诱导的肝损伤 (DILI) 进行分类,达到超过0.90 AUC. 这种自动化的文本分类有助于药物监督,并节省了审查员的资源.
科学领域:
- 药监和药物安全 药监和药物安全
- 计算毒理学计算毒理学
- 监管科学 监管科学
背景情况:
- 监管机构生成大量的文本数据,包括药物标签,这对于传达安全性和有效性至关重要.
- 药品标签是药物监督,药物安全研究和FDA和EMA等机构监管审查的重要资源.
- 自动化文本分类可以增强药品标签文件的分析,并优化审查员资源分配.
研究的目的:
- 开发和评估一种基于人工智能的文本分类模型,用于识别药物标签文件中的药物诱导性肝损伤 (DILI) 内容.
- 利用文本挖掘和机器学习技术来提高分析法规文本数据的效率和准确性.
主要方法:
- 利用人工智能,特别是文本挖掘和XGBoost模型,对DILI相关内容进行分类.
- 员工首选术语从医学查询中获取不良事件标准,通过保留医学术语和删除常用短语来完善文本数据.
- 使用术语频率-反向文档频率 (TF-IDF) 权重构建了一个文档术语矩阵,用于单词/术语/令牌分析.
主要成果:
- 自动化文本分类模型在预测DILI方面表现强.
- 在美国食品和药物管理局 (FDA) 和欧洲医疗机构 (EMA) 药物标签上,实现了超过0.90的交叉验证曲线下区域 (AUC) 评分.
- 该模型还在CAMDA (大规模数据分析的批判性评估) 数据集中的文献摘要上表现强.
结论:
- 开发的文本挖掘和XGBoost方法为药物标签中的DILI相关内容的自动分类提供了一个强大的方法.
- 该模型的高性能表明其有潜力显著改善监管文件的分析,并支持药监督工作.
- 展示的文字处理和分类技术适用于更广泛的文本分析任务在监管科学和超越.
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