尿道帕拉本与尼日利亚男性的精子质量之间的关联:一项病例对照研究
Friday Ebhodaghe Okonofua1,2,3, Lorretta Favour Chizomam Ntoimo1,3,4, Emmanuel Unuabonah5,6
1Centre of Excellence in Reproductive Health Innovation (CERHI), University of Benin, Benin, Edo State, Nigeria.
International journal of general medicine
|June 18, 2024
概括
尿中的类含量与尼日利亚男性的精子质量降低有关,包括运动性和形态学. 减少接触这些防腐剂可能有助于降低男性不孕率.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 男人的健康 男人的健康
背景情况:
- 烯是化品和药品中常见的防腐剂.
- 以前的研究表明,类对动物和人类模型中的精子质量产生负面影响.
- 尽管尼日利亚的产品使用量很高,但没有研究调查了对的暴露和精子质量.
研究的目的:
- 评估尿中类代谢物水平与尼日利亚男性精子质量之间的关联.
- 为了比较肥沃和不育男性的素水平.
主要方法:
- 一项多中心病例控制研究,涉及尼日利亚南部的136名不孕男性和154名不孕男性.
- 通过液态染色体质谱法测量尿中的甲水平 (乙,甲,,丁甲).
- 使用世卫组织标准和放射性免疫检测进行的精液分析和激素测定;数据分析使用非参数统计数据.
主要成果:
- 在不孕不育和肥沃的男性中检测到尿液中高水平的甲.
- 在不孕男性中,甲与精子总运动率和形态学有显著的负面关联.
- 血清丸激素水平与尿中的甲度没有显著的相关性.
结论:
- 尿路暴露于素与精子质量受损有关,特别是精子的运动性,形态和体积.
- 在尼日利亚,减少男性接触含的产品可能会降低男性不孕症的发生率.
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